Allergy/Imm Medical News about CYP3A5 Genotype

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Effect of CYP3A5 Genotype on Renal Allograft Recipients Treated With Tacrolimus
Transplantation Proceedings, 06/26/09

Chen JS et al. - Tacrolimus concentrations are associated with CYP3A5 genotype. This study suggested to choose the initial dosage according to the CYP3A5 genotype to obtain a better outcome and reduce the incidences of acute rejection episodes and nephrotoxicity.

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Black renal transplant recipients have poorer long-term graft survival than CYP3A5 expressers from other ethnic groups
Nephrology Dialysis Transplantation, 10/14/09 Relevance Score: 42%

CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men
Journal of Human Hypertension, 10/12/09 Relevance Score: 42%

CYP3A4 and CYP3A5 Polymorphisms and Blood Pressure Response to Amlodipine among African-American Men and Women with Early Hypertensive Renal Disease
American Journal of Nephrology, 11/12/09 Relevance Score: 40%

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
Pharmacogenetics and genomics, 10/30/09 Relevance Score: 40%

Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in De Novo Pediatric Kidney Transplant Recipients
Clinical Pharmacology & Therapeutics, 10/29/09 Relevance Score: 40%