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See Latest ArticlesWhy is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Immunology & Cell Biology, 06/24/09
Voelkel NF et al. - A molecular model of the pathobiology of asthma can be built by connecting hypoxia-inducible transcription factor-1 alpha, VEGF S1P, and bone-marrow precursor cell mobilization and acknowledging that angiogenesis is part of the inflammatory response.
Dr NF Voelkel, 06/24/09
| The message of this 'hypothesis paper' is that asthma is likely more than an airway disease. A modern view of chronic and progressive lung diseases departs from the concept of compartment restriction of the diseases. For example: interstitial fibrosis also involves the lung vessels and COPD is also a systemic disorder. Breaking down the compartment restriction the pathobiology can be investigated in its entirety and the systems biology approach will likely lead to new treatment strategies rather than to the development of just another bronchodilator for the treatment of asthma. |
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