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Ovarian Cancer-derived Glycodelin Impairs In Vitro Dendritic Cell Maturation
Journal of Immunotherapy, 06/24/09

Scholz C et al. - Functional data provided further evidence for the immature/tolerogenic properties of Gd-pretreated DCs. Antigen uptake was retained, production of interleukin-10 was increased, and lymphoproliferative activity was reduced. This effect was reversible by adding Gd-blocking antibodies. Gd, which is found in the malignant ascites of ovarian cancer patients, induces a tolerogenic phenotype in DC, thereby shaping an immunodeficient tumor micromilieu.

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