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See Latest ArticlesCholinergic Neural Signals to the Spleen Down-Regulate Leukocyte Trafficking via CD11b
Journal of Immunology, 06/25/09
Huston JM et al. - Studies demonstrate that modulation of leukocyte trafficking via cholinergic signaling to the spleen is a specific, centralized neural pathway positioned to suppress the excessive accumulation of neutrophils at inflammatory sites. Activating this mechanism may have important therapeutic potential for preventing tissue injury during inflammation.
Dr. Christine N. Metz, 06/26/09
| These findings support the hypothesis that the spleen 'educates' circulating and/or stored neutrophils (via cell-based or soluble factors) to regulate their trafficking during inflammation and that this can be controlled, in part, by cholinergic stimulation. |
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