Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Novel therapies for children with severe asthma
Top Ten Searches
hla beta 2 probiotics hypo allergenic scid urticaria aeroallergens asthma angioedema hivYour Article Summary
See Latest ArticlesAltered Thymic Selection and Increased Autoimmunity Caused by Ectopic Expression of DRAK2 during T Cell Development
Journal of Immunology, 06/23/09
Gatzka M et al. - These findings suggest that alteration in thymocyte signaling thresholds impacts the sensitivity of peripheral T cell pools.
Dr. Craig M. Walsh, 06/23/09
| In this work, we ectopically expressed the serine/threonine kinase DRAK2 in thymocytes. In previous work, we have established that DRAK2 negatively regulates T cell activation in peripheral T cells and late thymocyte populations. Here, we demonstrate that expression of DRAK2 in the double-positive stage, where it is normally expressed only at very low levels, diminishes thymocyte selection. This is likely due to the artificially high activation barrier imposed by DRAK2. The surprising result is that peripheral T cells obtained from these mice have a reduced activation threshold compared to wildtype T cells (and the transgenic DRAK2 is not expressed in these peripheral cells). Our findings suggest that imposition of a high signaling threshold during thymocyte selection leads to the development of peripheral T cells with enhanced T cell antigen receptor (TCR)signaling properties. These studies underscore the concept that any T cell therapies directed toward manipulating TCR signaling should take into account potential effects during T cell development in the thymus. |
Today in Endocrine...keeping you current
Receive free subspecialty "5-minute updates" via email
The Differences in Blood Levels of Lipids, Adipokines, and Proinflammatory Cytokines Among Normal, Overweight, and Obese Korean Women
The Endocrinologist, 11/16/09
Obesity and low-grade inflammation: a paediatric perspective
Obesity Reviews, 11/02/09
Clinical Applications of Diabetes Antibody Testing
Journal of Clinical Endocrinology and Metabolism, 11/02/09
Today in Rheumatic/Autoimmune...keeping you current
Receive free subspecialty "5-minute updates" via email
Vaccination, atherosclerosis and systemic lupus erythematosus
Lupus, 11/05/09
Update in treatment options for psoriatic arthritis
Expert Review of Clinical Immunology, 11/23/09
Safety of vaccination of patients with systemic lupus erythematosus
Lupus, 11/04/09
Sponsor
Article Search
Sponsor