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Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of V alpha 24 Invariant NKT Cells
Journal of Immunology, 06/23/09
Uemura Y et al. - The results suggest that iNKT cells modify the IL-12p70/IL-23 balance to enhance the IL-12p70-induced cell-mediated immunity and suppress the IL-23-dependent inflammatory pathologies. These results may account for the long-appreciated contrasting beneficial and adverse consequence of ligand activation of iNKT cells.
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Alanine mutagenesis of the primary antigenic escape residue cluster (C1) of Apical Membrane Antigen-1
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