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Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism
Journal of Immunology, 06/23/09
Shurin GV et al. - These findings reveal a new mechanism of immunopotentiating activity of chemotherapeutic agents—a direct immunostimulatory effect on DCs—and thus provide a strong rationale for further assessment of low-dose chemotherapy given with DC vaccines for cancer treatment.
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