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Kayed R et al. - Considerable effort over the last decade has been directed toward the development of vaccines for AD; these have been primarily directed against the A beta peptide, a component of senile plaques. More recently, alternative approaches have begun to target the microtubule binding protein tau, a component of neurofibrillary tangles. Immunotherapies based upon oligomeric species of tau represent a promising new approach for AD.

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