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See Latest ArticlesAccuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine
Brain, 06/17/09
Rosi S et al. - These data suggest that during chronic neuroinflammation, the CA3 networks show a disrupted ability to encode spatial information, and that CA1 neurons can work independently of CA3. Importantly, memantine treatment is able to partially normalize information processing in the hippocampus, suggesting that when given early during the development of the pathology memantine confers neuronal and cognitive protection while indirectly prevents pathological microglial activation.
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