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Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
Journal of Experimental Medicine, 06/10/09

Kuang DM et al. - The authors found that PD-L1 expression on tumor-infiltrating monocytes increased with disease progression, and the intensity of the protein was associated with high mortality and reduced survival in the HCC patients. Thus, expression of PD-L1 on activated monocytes/M varphi may represent a novel mechanism that links the proinflammatory response to immune tolerance in the tumor milieu.

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