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Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
Journal of Experimental Medicine, 06/10/09

Kuang DM et al. - The authors found that PD-L1 expression on tumor-infiltrating monocytes increased with disease progression, and the intensity of the protein was associated with high mortality and reduced survival in the HCC patients. Thus, expression of PD-L1 on activated monocytes/M varphi may represent a novel mechanism that links the proinflammatory response to immune tolerance in the tumor milieu.

Today in Gastrointestinal/Hepatic...keeping you current

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Autoimmune Hepatitis Type 2 Arising in PFAPA Syndrome: Coincidences or Possible Correlations
Pediatrics, 03/16/10

Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress
Inflammation Research, 03/16/10

Immunologic Abnormality of Intrahepatic Cholestasis of Pregnancy
American Journal of Reproductive Immunology, 03/15/10

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Today in Hematology/Oncology...keeping you current

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Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood
European Journal of Immunology, 03/16/10

The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors
European Journal of Immunology, 03/16/10

Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran
Inflammation Research, 03/16/10

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