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Reciprocal regulation of 17 beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer
Cytokine, 06/04/09
Yang J et al. - These results provide a novel mechanism that estrogens, IL-6 and IL-8 may form a common amplifying signaling cascade to modulate OVCA growth and progression. Estrogen-induced OVCA proliferation is partially occurring via enhanced IL-6 and IL-8 production and modulated their receptors, and IL-6/IL-8 could also promote OVCA growth through an ER alpha pathway.
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