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Factors regulating circulating vascular endothelial growth factor (VEGF): Association with bone mineral density (BMD) in post-menopausal osteoporosis
Cytokine, 06/05/09

Costa N et al. - Findings suggest that polymorphic variants in the vascular endothelial growth factor (VEGF) gene are associated with spine bone mineral density (BMD). Further larger studies are needed.

Methods

An investigation of the factors that influence circulating VEGF and their association with BMD
252 post-menopausal women; mean age: 64.5 yrs
BMD was determined at the lumbar spine (LS), femoral neck (FN) and total hip (TH)
Serum oestradiol and VEGF were measured
Subjects were genotyped for 2 polymorphic variants in the 5′ untranslated region of the VEGF gene; G(634)C and C(936)T

Results

Positive correlations were seen between circulating VEGF and BMI and oestradiol
Serum VEGF was associated with the G(634) polymorphism and dietary calcium intake
In vitro studies: association with calcium intake could be mediated by parathyroid hormone (PTH)
Following correction for confounders, there was no association between circulating VEGF and BMD at any site
Both VEGF polymorphisms were significant predictors of LS BMD
Circulating VEGF may be influenced by genetic, environmental and endocrine factors

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