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Soerli J et al. - The authors show here that human monoclonal IgG antibodies with specificity for variant surface antigens specifically expressed by CSA-adhering IEs can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.

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