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Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor
Immunity, 05/26/09
Lafaille MACD et al. - The authors speculate that iTreg cell development is driven by the need to maintain a noninflammatory environment in the gut, to suppress immune responses to environmental and food allergens, and to decrease chronic inflammation, whereas nTreg cells prevent autoimmunity and raise the activation threshold for all immune responses.
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