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Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions
Clinical Immunology, 05/19/09
Pachiadakis I et al. - HCV genome/core protein, although detectable in DC from some patients had no effect on DC function. Antiviral immunity at TW12 was not improved in patients who remained HCV RNA positive, while early viraemia clearance improved antiviral responses. The cross-over experiment revealed that changes in DC, rather than CD4+T cells have a major role for enhanced anti-HCV responses.
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