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See Latest ArticlesA novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease
Neurobiology of Disease , 05/27/09
Mastroberardino PG et al. - This is associated with iron deposition in SN, similar to what occurs in PD. In the human SN, TfR2 is also found in mitochondria of dopamine neurons, and in PD there is a dramatic increase of oxidized Tf in SN. Thus, authors have discovered a novel mitochondrial iron transport system that goes awry in PD, and which may provide a new target for therapeutic intervention.
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