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Luteinizing Hormone-Releasing Hormone Enhances T Cell Recovery following Allogeneic Bone Marrow Transplantation
Journal of Immunology, 04/27/09
Goldberg GL et al. - This results in an increase in T cell function in vivo and in vitro. Graft-versus-host-disease is not exacerbated by LHRHa treatment and graft-versus-tumor activity is maintained. Because LHRHa allows for reversible sex steroid ablation, has a strong safety profile, and has been clinically approved for diseases such as prostate and breast cancer, this drug treatment represents a novel therapeutic approach to reversal of thymic atrophy and enhancement of immunity following immunosuppression.
Today in Endocrine...keeping you current
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The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
Journal of Experimental Medicine, 11/30/09
Treatment with the PPAR-gamma agonist rosiglitazone down-regulates interleukin-1 receptor antagonist in individuals with metabolic syndrome
European Journal of Endocrinology, 11/24/09
Autoimmune Polyglandular Syndrome Type 2 With Myasthenia Gravis Crisis
The Neurologist, 11/20/09
Today in Surgery/Transplantation...keeping you current
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TGF[beta] Neutralization within Cardiac Allografts by Decorin Gene Transfer Attenuates Chronic Rejection
Journal of Immunology, 11/30/09
Type I Interferons Are Not Critical for Skin Allograft Rejection or the Generation of Donor-Specific CD8+ Memory T Cells
American Journal of Transplantation, 11/30/09
Effects of Prophylactic Splenic Artery Modulation on Portal Overperfusion and Liver Regeneration in Small-for-Size Graft
Transplantation, 11/25/09
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