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See Latest ArticlesDifferential effects of immunosuppressive drugs on COX-2 activity in vitro and in kidney transplant patients in vivo
Nephrology Dialysis Transplantation, 04/22/09
Jespersen B et al. - Although CsA suppressed COX-2 in cultured vascular smooth muscle cells, systemic prostacyclin was not suppressed by either CsA or tacrolimus in vivo. Rapamycin and tacrolimus may actively suppress platelet and renal thromboxane formation. Differential changes in prostanoids may have implications for long-term cardiovascular hazard in patients treated with immunosuppressives.
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