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See Latest ArticlesDrak2 Is Upstream of p70S6 Kinase: Its Implication in Cytokine-Induced Islet Apoptosis, Diabetes, and Islet Transplantation
Journal of Immunology, 04/09/09
Mao J et al. - The authors established that inducible NO synthase was upstream and caspase-9 was downstream of Drak2 in its signaling pathway. Purified Drak2 could phosphorylate ribosomal protein S6 (p70S6) kinase in an in vitro kinase assay. Drak2 overexpression in NIT-1 cells led to enhanced p70S6 kinase phosphorylation, whereas Drak2 knockdown in these cells reduced it. These mechanistic studies proved that p70S6 kinase was a bona fide Drak2 substrate.
Today in Endocrine...keeping you current
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Processing in the Endoplasmic Reticulum Generates an Epitope on the Insulin A Chain that Stimulates Diabetogenic CD8 T Cell Responses
Journal of Immunology, 12/01/09
The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
Journal of Experimental Medicine, 11/30/09
Treatment with the PPAR-gamma agonist rosiglitazone down-regulates interleukin-1 receptor antagonist in individuals with metabolic syndrome
European Journal of Endocrinology, 11/24/09
Today in Surgery/Transplantation...keeping you current
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Intact LFA-1 deactivation promotes T-cell activation and rejection of cardiac allograft
International Immunology, 12/01/09
Absence of Donor-Specific Anti-HLA Antibodies After ABO-Incompatible Heart Transplantation in Infancy: Altered Immunity or Age
American Journal of Transplantation, 12/01/09
Tacrolimus enhances transforming growth factor-[beta]1 expression and promotes tumor progression
Transplantation, 12/01/09
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