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Reduced intradermal test dose of yellow fever vaccine induces protective immunity in individuals with egg allergy
Vaccine , 04/14/09
Roukens AH et al. - The neutralising antibody response after the yellow fever vaccine skin test was measured in 7 egg allergic persons in whom further vaccination was abandoned because of a strong local urticarial reaction to the YF-17D vaccine test dose. The authors found that this test dose of 0.1 mL of YF-17D vaccine was sufficient to induce a protective antibody response in all 7 subjects. Intradermal injection of 1/5th dose of the yellow fever vaccine appears to be sufficient, in non-allergic as well as allergic persons, and non-inferior to the subcutaneous full dose.
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