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See Latest ArticlesBenefits and burden of the maternally-mediated immunological imprinting
Autoimmunity Reviews, 03/20/09
Lemke H et al. - These exert up to life-long determinative influences which may even be dominant over seemingly genetic predispositions. Such long-term immunological imprinting effects can be detected as selection of the adult T and B cell repertoires, anti-microbial protection by antigen-reactive antibodies and anti-idiotypes, allergen-specific suppression of IgE responsiveness by allergen-reactive IgG idiotype or corresponding anti-idiotype and induction of autoimmune diseases by maternally-derived autoantibodies. Hence, immunological imprinting by maternal IgG antibodies will mostly be beneficial, but in case of autoantibodies can also be a burden for the initial development of the nascent immune system.
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