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See Latest ArticlesThe Co-operative Specificity Theory: Phenotypic protection from T1D by certain HLA Class II DRB1 and DQ alleles identifies the absence of co-operation between the respective DR and DQ molecules eventuating in no T1D-predisposition
Autoimmunity Reviews, 04/09/09
Temajo NO et al. - It is well established that both DR and DQ genes are involved in type 1 diabetes (T1D) -susceptibility. It is a situation of co-operative participation restricted to a specific DR- and its corresponding specific DQ-molecules that results in susceptibility. Thus susceptibility may not result when a corresponding specific DR or DQ allele is substituted by a non-specific allele in the haplotype. It thus ensues that phenotypic protection identifies the absence of this specific co-operation between the respective DR and DQ molecules giving rise to no predisposition.
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A retrospective review of clinical presentation, thyroid autoimmunity, laboratory characteristics, and therapies used in patients with chronic idiopathic urticaria
Annals of Allergy, Asthma, and Immunology, 12/16/09
Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction
Journal of Immunology, 12/16/09
Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens
Journal of Immunology, 12/11/09
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