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Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis
Genes and Immunity, 03/13/09

Hewagama A et al. - In contrast, IL17A was the only effector gene more highly expressed in men. Estrogen response elements were identified in the promoters of half the overexpressed immune genes in women, and in <10% of the male-biased genes. The differential expression of inflammatory/cytotoxic effector molecules in restimulated female T cells may contribute to the differences in autoimmune diseases between women and men.

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