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See Latest ArticlesThymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes
European Journal of Immunology, 03/13/09
Gommeaux J et al. - The authors showed that the absence of TSSP markedly impaired the selection of Marilyn and OT-II CD4+ T cells. In contrast, selection of CD8+ T cells expressing an MHC class I-restricted TCR transgene was unaffected. Therefore, TSSP is involved in the positive selection of some CD4+ T lymphocytes and likely constitutes the first serine protease to play a function in the intrathymic presentation of self-peptides bound to MHC class II complexes.
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