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Antimicrobial properties of melanocortins: comment to the manuscript "Anti-Candida activity of alpha-melanocyte-stimulating hormone (alpha-MSH) peptides" by Isabella Rauch et al.
Journal of Leukocyte Biology, 03/03/09

Catania A et al. - It should be considered that in physiological conditions, there is sustained peptide release by host cells in an autocrine/paracrine manner. However, when the procedure described in the paper published in the Journal Leukocyte Biology was used, the investigation by Rauch et al. found that concentrations of alpha-MSH in the high micromolar range have candidacidal activity.

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