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Vitale G et al. - The data demonstrate that the IGF system has an important role in autocrine/paracrine growth of BON cells. The more potent antitumor activity of IFN-beta compared with IFN- could be explained by several effects on this system: both IFNs inhibit the transcription of IGF-II, but the suppression is significantly higher after IFN-beta than IFN- and only IFN-beta inhibits the expression of IGF-I receptor.

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