HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells
Journal of Neuroimmunology, 06/12/2012Wolpert F et al.
Constitutive HLA–E inhibits natural killer (NK) cell–mediated lysis of GIC since small–interfering RNA–mediated HLA–E gene silencing enhances the immunogenicity of GIC. Increased GIC lysis was observed both in the CD133+ and in the CD133- compartment. Furthermore, the use of interferon–γ as a possible agent to boost an immune response against glioblastoma cells might be limited by the concurrent upregulation of HLA–E.
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