HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells

Journal of Neuroimmunology, 06/12/2012

Constitutive HLA–E inhibits natural killer (NK) cell–mediated lysis of GIC since small–interfering RNA–mediated HLA–E gene silencing enhances the immunogenicity of GIC. Increased GIC lysis was observed both in the CD133+ and in the CD133- compartment. Furthermore, the use of interferon–γ as a possible agent to boost an immune response against glioblastoma cells might be limited by the concurrent upregulation of HLA–E.

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