Antibodies and carbohydrate ligands binding to C-type lectin DC-SIGN differentially modulate receptor trafficking

European Journal of Immunology, 06/04/2012

DC–SIGN showed a poor ability to accumulate targeting Abs within DCs. Vaccine efficacy may therefore be enhanced by strategies increasing the amount of Ag entering via a single receptor molecule, such as the use of targeting moieties allowing DC–SIGN recycling or Ab–coated vaccine carriers.

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