Antibodies and carbohydrate ligands binding to C-type lectin DC-SIGN differentially modulate receptor trafficking
European Journal of Immunology, 06/04/2012Tacken PJ et al.
DC–SIGN showed a poor ability to accumulate targeting Abs within DCs. Vaccine efficacy may therefore be enhanced by strategies increasing the amount of Ag entering via a single receptor molecule, such as the use of targeting moieties allowing DC–SIGN recycling or Ab–coated vaccine carriers.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.