Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac disease

Mucosal Immunology, 05/10/2012

Both size and dynamics of mucosa–associated and circulating IL–17A+ T–cell pools are finely regulated in human pediatric subjects, and severely disturbed in celiac disease (CD). The impaired IL–17A+ intraepithelial lymphocytes (IEL))–T pool may negatively impact on epithelial barrier efficiency, and contribute to CD mucosa damage; the disturbed dynamics of circulating IL–17A+ and IFN–γ+ T–cell pools may be involved in the extraintestinal autoimmune manifestations associated with CD.

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