Preclinical Evaluation of the HIV-1 Fusion Inhibitor L'644 as a Potential Candidate Microbicide

Antimicrobial Agents and Chemotherapy, 04/18/2012

L'644 was also more active than other FIs against a viral escape mutant resistant to reverse transcriptase inhibitors (RTIs), demonstrating the potential of L'644 to be included as part of a multiactive antiretroviral (ARV) combination–based microbicide. These data support the further development of L'644 for microbicide application.

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