Neuronal antigens recognized by cerebrospinal fluid IgM in multiple sclerosis

Journal of Neuroimmunology, 04/13/2012

The authors document for the first time that these IgM–Ab recognize neuronal surface antigens, and that the levels of neuronal–bound IgM–Ab were independent of the IgM concentration and correlate with brain atrophy. The findings suggest a role for the CSF IgM–Ab in the development of MS pathophysiology.

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