Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy

The Journal of Allergy and Clinical Immunology, 03/30/2012

After corticosteroid treatment, patients with the nonneutrophilic phenotype had significantly greater reductions in bilateral polyp size scores, nasal congestion scores, total nasal symptom scores, and nasal resistance than patients with the neutrophilic phenotype.There are different phenotypes of NPs based on the type of immune cell infiltrate and cytokines produced. Patients with the neutrophilic phenotype have less response to treatment with corticosteroids based on symptom

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