Thrombin induces an inflammatory phenotype in a human brain endothelial cell line

Journal of Neuroimmunology, 03/02/2012

The authors show that thrombin increased the mRNA and cell surface levels of ICAM–1 and VCAM–1 in hCMEC/D3 cells. Thrombin similarly upregulated several chemokines implicated in human neurological conditions. Additionally, the paracellular permeability of the human blood–brain barrier (BBB) in vitro was also increased following thrombin treatment. Overall, this study demonstrates that thrombin can effectively induce an inflamed phenotype in an in vitro human BBB.

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