Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

European Journal of Immunology, 02/22/2012

Protein kinase D (PKD)2–deficient lymphocytes, as well as DT40 cells devoid of any PKD isoforms, could activate Rap1 in response to BCR ligation or phorbol ester treatment. These results show that the PKD family does not play a critical role in lymphocyte integrin–mediated cell adhesion or lymphocyte trafficking in vivo.

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