Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+FoxP3+ T cells

Clinical and Experimental Immunology, 08/05/2011

Piper KP et al.– This work demonstrates that patients with chronic lymphocytic leukaemia (CLL) exhibit a systemic T cell dysregulation leading to the accumulation of CD4+FoxP3+ T cells. This appears to be driven by interaction with malignant cells and increased understanding of the mechanisms that are involved could provide novel avenues for treatment.

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