Mahdy AM et al.– H1 antihistamines have well–documented anti–allergic and anti–inflammatory effects and are well established in the treatment of a variety of allergic disorders. First–generation antihistamines are also used in the treatment of vestibular disorders and can be used as sedatives, sleeping aids and anti–emetics. H2 antihistamines are widely used in the treatment of gastric acid–related disorders; however, proton pump inhibitors are becoming the drugs of first choice in some of these disorders. H3 antihistamines are expected to be of potential value in the treatment of some cognitive disorder. H4 antihistamines could be of potential therapeutic benefit in the management of various immune and inflammatory disorders.
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