Cholinergic Neural Signals to the Spleen Down-Regulate Leukocyte Trafficking via CD11b Huston JM et al. - Studies demonstrate that modulation of leukocyte trafficking via cholinergic signaling to the spleen is a specific, centralized neural pathway positioned to suppress the excessive accumulation of neutrophils at inflammatory sites. Activating this mechanism may have important therapeutic potential for preventing tissue injury during inflammation. [more...]
