Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders Kayed R et al. - Considerable effort over the last decade has been directed toward the development of vaccines for AD; these have been primarily directed against the A beta peptide, a component of senile plaques. More recently, alternative approaches have begun to target the microtubule binding protein tau, a component of neurofibrillary tangles. Immunotherapies based upon oligomeric species of tau represent a promising new approach for AD. [more...]
