Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection Das A et al. - Authors provide evidence for depletion of arginine in the inflamed hepatic microenvironment as a potential mechanism for these defects in global CD8 T cell signaling and function. Data imply that polarized CD8 T cells within the HBV-infected liver may impede proliferative antiviral effector function, while contributing to the proinflammatory cytokine environment. [more...]
