Failure of omalizumab in cholinergic urticaria
Clinical and Experimental Dermatology, 11/25/2009
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Sabroe RA – Cholinergic urticaria is one of the more common physical urticarias. Although it is often fairly mild, severe treatment–resistant disease may occur, with significant associated disability. Omalizumab, a monoclonal IgG anti ... severe asthma, has recently been used successfully in several types of urticaria, including in one case of cholinergic urticaria.
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The definition and diagnostic testing of physical and cholinergic urticarias - EAACI/GA2LEN/EDF/UNEV consensus panel recommendations
Allergy, 11/16/2009
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Magerl M et al. – The authors' recommendations used the paper produced by a 1996 expert meeting and they acknowledge the latest changes in our understanding of physical urticarias and cholinergic urticaria as well as the ... recent development of novel diagnostic tools. In addition, this consensus paper highlights areas of need for further research.
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Chronic urticaria and treatment options
Indian Journal of Dermatology, 11/20/2009
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Godse KV – Chronic urticaria (CU) has a wide spectrum of clinical presentations and causes. An affected patient often goes from one dermatologist to another in pursuit of a cure. Despite a dermatologist's best efforts no cause can be found in most ... 30–50% of patients with chronic idiopathic urticaria (CIU) have circulating histamine releasing autoantibodies to the high–affinity IgE receptor FceRI on basophils and mast cells or, less commonly, antibodies to IgE.
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An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment
Dermatologic Therapy, 11/20/2009
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Vena GA et al. – Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is ... available evidence suggests the involvement of mast cells through non–immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines.
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Prevalence and relevance of skin autoreactivity in chronic urticaria
Expert Review of Dermatology, 12/03/2009
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Krause K et al. – This review focuses on the prevalence and relevance of skin autoreactivity in chronic spontaneous urticaria. It describes diagnostic procedures and treatment options and gives an outlook on how to improve the management of autoreactive urticaria.
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Outpatient urticaria diagnosis codes have limited predictive value for same-day influenza vaccine adverse event detection
Journal of Clinical Epidemiology, 11/09/2009
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Moore KM et al. – Outpatient diagnosis codes for urticaria found in health insurance claims data are limited in their predictive value to identify same–day vaccine ... allergy/immunology,derm allergy/immunology,adverse drug reactions,dermatology,diagnostics/radiology
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Effects of a pseudoallergen-free diet on chronic spontaneous urticaria: a prospective trial
Allergy, 12/17/2009
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Magerl M et al. – Altogether the pseudoallergen–free diet is beneficial for one in three patients. The pseudoallergen–free diet is a safe, healthy and cost–free measure to identify patients with chronic spontaneous urticaria that will benefit ... from avoiding pseudoallergens.
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Methotrexate: a useful steroid-sparing agent in recalcitrant chronic urticaria
British Journal of Dermatology, 11/24/2009
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Grattan C et al. – Methotrexate may be a useful treatment for steroid–dependent chronic urticaria. Functional autoantibodies do not correlate with response. The beneficial effects of methotrexate may be anti ... chronic urticaria independently of the pathogenic mechanism, whether autoimmune or not.
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Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensitivity in patients with chronic urticaria: diagnosis and follow-up
Clinical and Experimental Dermatology, 11/02/2009
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Frezzolini A et al. – BAT can be considered a reliable new in vitro method to evaluate A. simplex hypersensitivity in patients with CU ... genetics,dermatology
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Familial atypical cold urticaria: Description of a new hereditary disease
Journal of Allergy and Clinical Immunology, 11/25/2009
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Gandhi C et al. – FACU is a new cold–induced inherited disease that is different than ACU in its natural history, atmospheric cold elicitation, severity of systemic reactions, and CSTT results. FACU differs from ... in symptom timing and the absence of fever, chills, and joint pain. The cause is suspected to be mast cell related. Treatment of reactions is similar to that for ACU. Further evaluation of pathogenesis and genetics is warranted.
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