Top hla Articles in Allergy/Immunology

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia
Arthritis Research & Therapy, 11/17/2009

Paladini F et al. – The aim of the current study is to assess the occurrence of an additional HLA susceptibility locus in the region between HLA-E and HLA-C in the Sardinian population. There is a strong association between ... the presence of a haplotype in genes mapping between HLA-E and HLA-C and AS due to an increase of homozygous markers in patients. The strongest association however, is with the HLA-E functional polymorphism rs1264457. Since HLA-E is the ligand for the NKG2A receptor, these data point to the natural ... of AS. Methods 200 random controls, 120 patients with AS and 175 HLA-B27 positive controls genotyped for 6 single nucleotide polymorphisms (SNPs) spanning HLA region between HLA-E and HLA-C loci previously shown to harbour an additional susceptibility locus for AS HLA-E polymorphism (Arg128/Gly128) Genotype distribution of 3 other SNPs mapping in genes (GNL1, PRR3 and ABCF-1) close to HLA-E and showing high LD with it, also significantly skewed Accordingly ... 42% in random controls, increases to 53% in HLA-B27-positive controls, and reaches 68% in patients with AS (P values: 2x10-11 vs random and 3x10-4 vs HLA-B27 controls) [more...]

The HLA-ER/HLA-ER Genotype Affects the Natural Course of Hepatitis C Virus (HCV) Infection and Is Associated with HLA-E–Restricted Recognition of an HCV-Derived Peptide by Interferon[gamma]–Secreting Human CD8+ T Cells
The Journal of Infectious Diseases, 10/14/2009

Schulte D et al. – The authors showed chronic hepatitis C to be ... increased expression of HLA-E and identified peptide hepatitis C virus (HCV) core amino acids 35–44 as a ligand for HLA-E that stabilizes HLA-E expression, favoring inhibition of natural killer cell cytotoxicity. The data indicate an important immunomodulating function of HLA-E in hepatitis C [more...]

Successful hematopoietic stem cell transplantation in two children with X-linked chronic granulomatous disease from their unaffected HLA-identical siblings selected using pre-implantation genetic diagnosis combined with HLA-typing
Biology of Blood and Marrow Transplantation, 10/22/2009

Goussetis E et al. – The present report demonstrates that HSCT with HLA–matched sibling donors created by PGD/HLA typing of in vitro fertilized embryos is a ... and should be presented as such to families with children who need a non–urgent HSCT but lack an HLA–genoidentical donor. [more...]

Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience
Transplantation Proceedings, 11/18/2009

Kekik C et al. – Seropositive patients without aGvHD but with posttransplantation CMV infection demonstrated a higher incidence of HLA–A30 ... HLA–B40, and HLA–DRB1*15 compared with those without CMV infection. It seems that certain HLA alleles may have either a protective or predisposing role in CMV reactivation, which might be helpful in estimating the risk of aGvHD and designing individualized therapy. [more...]

Low-dose total body irradiation and fludarabine conditioning for HLA-class I mismatched donor stem cell transplantation and immunological recovery in patients with hematological malignancies
Biology of Blood and Marrow Transplantation, 11/13/2009

AuthorLastNameFI et al. – HLA-mismatched grafts are a viable alternative source for patients without HLA-matched donors receiving ablative ... conditioning HCT has been not well established.Nonmyeloablative conditioning with fludarabine and low-dose TBI followed by HCT using HLA-class I mismatched donors leads to successful engraftment and long-term survival. Methods 59 patients conditioned with fludarabine 90mg/m2 ... stimulating factor-mobilized peripheral blood cells from related (n=5) or unrelated donors (n=54) with one antigen ± 1 allele HLA-class I mismatch or 2 HLA-class I allele mismatches Results Sustained donor engraftment observed in 95% of evaluable patients [more...]

Soluble Human Leukocyte Antigen-G Isoforms in Maternal Plasma in Early and Late Pregnancy
American Journal of Reproductive Immunology, 10/13/2009

detectable soluble HLA–G concentration in maternal plasma or serum is not mandatory for a successful pregnancy. This study indicates that sHLA–G1 is the interesting soluble HLA–G isoform in pre–eclampsia, and that low or undetectable levels of HLA–G5 at the end of ... associated with an uncomplicated normal pregnancy, whereas in severe pre–eclampsia and possibly other pregnancy complications, such as preterm birth and IUGR, the level of HLA–G5 is higher. [more...]

HLA-class I markers and multiple sclerosis susceptibility in the Italian populationGENEOpen
Genes and Immunity, 11/20/2009

Bergamaschi L et al. – Previous studies reported an association with multiple sclerosis (MS) of distinct HLA–class I markers, namely HLA–A*02, HLA–Cw*05 and MOG–142L. In the [more...]

Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer
Cancer Immunology, Immunotherapy, 10/26/2009

Seliger B et al. – Results suggest that HLA class I APM component abnormalities are mainly due to regulatory mechanisms, play a role in the clinical course of prostate cancer and on ... the cytoplasm of normal prostate cells, whereas HLA class I heavy chain (HC) and ?2-microglobulin are expressed on the cell surface Most of APM components downregulated in substantial number of prostate cancers With exception of HLA class I HC, TAP2 and ERp57 not detectable in ... early disease recurrence Prostate carcinoma cell lines also exhibit heterogeneous, but reduced constitutive APM component expression pattern associated with lack or reduced HLA class I surface antigens, which could be upregulated by IFN-&upsilon [more...]

The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes
Genes and Immunity, 10/06/2009

Castelli EC et al. – A high linkage disequilibrium among the variation sites was detected, especially among the 14–bp insertion and the alleles +3142G and +3187A, all previously associated ... effects are not independent. The detailed analyses of 3'UTR of the HLA–G locus may shed some light into mechanisms underlying the regulation of HLA–G expression. [more...]

HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children
Digestive and Liver Diseases, 10/13/2009

Alarida K et al. – HLA–DQ2 and –DQ8 in CD patients are as common in Libya as in Italy, but the frequency of "high–risk" genotypes is higher in Libyan than Italian patients. The prevalence of HLA–DQ2 and [more...]