Top hla Articles in Allergy/Immunology

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia
Arthritis Research & Therapy, 11/17/2009

Paladini F et al. – The aim of the current study is to assess the occurrence of an additional HLA susceptibility locus in the region between HLA-E and HLA-C in the Sardinian population. There is a strong association between ... the presence of a haplotype in genes mapping between HLA-E and HLA-C and AS due to an increase of homozygous markers in patients. The strongest association however, is with the HLA-E functional polymorphism rs1264457. Since HLA-E is the ligand for the NKG2A receptor, these data point to the natural ... of AS. Methods 200 random controls, 120 patients with AS and 175 HLA-B27 positive controls genotyped for 6 single nucleotide polymorphisms (SNPs) spanning HLA region between HLA-E and HLA-C loci previously shown to harbour an additional susceptibility locus for AS HLA-E polymorphism (Arg128/Gly128) Genotype distribution of 3 other SNPs mapping in genes (GNL1, PRR3 and ABCF-1) close to HLA-E and showing high LD with it, also significantly skewed Accordingly ... 42% in random controls, increases to 53% in HLA-B27-positive controls, and reaches 68% in patients with AS (P values: 2x10-11 vs random and 3x10-4 vs HLA-B27 controls) [more...]

Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center Experience
Transplantation Proceedings, 11/18/2009

Kekik C et al. – Seropositive patients without aGvHD but with posttransplantation CMV infection demonstrated a higher incidence of HLA–A30 ... HLA–B40, and HLA–DRB1*15 compared with those without CMV infection. It seems that certain HLA alleles may have either a protective or predisposing role in CMV reactivation, which might be helpful in estimating the risk of aGvHD and designing individualized therapy. [more...]

Low-dose total body irradiation and fludarabine conditioning for HLA-class I mismatched donor stem cell transplantation and immunological recovery in patients with hematological malignancies
Biology of Blood and Marrow Transplantation, 11/13/2009

AuthorLastNameFI et al. – HLA-mismatched grafts are a viable alternative source for patients without HLA-matched donors receiving ablative ... conditioning HCT has been not well established.Nonmyeloablative conditioning with fludarabine and low-dose TBI followed by HCT using HLA-class I mismatched donors leads to successful engraftment and long-term survival. Methods 59 patients conditioned with fludarabine 90mg/m2 ... stimulating factor-mobilized peripheral blood cells from related (n=5) or unrelated donors (n=54) with one antigen ± 1 allele HLA-class I mismatch or 2 HLA-class I allele mismatches Results Sustained donor engraftment observed in 95% of evaluable patients [more...]

RREB-1 Is a Transcriptional Repressor of HLA-G1
Journal of Immunology, 11/30/2009

Flajollet S et al. – RREB–1 protein, specifically in HLA–G–negative cells, interacts with subunits of CtBP complex implicated in chromatin remodeling. This demonstration is the first of a repressor factor of HLA–G transcriptional activity taking part in HLA [more...]

HLA-class I markers and multiple sclerosis susceptibility in the Italian populationGENEOpen
Genes and Immunity, 11/20/2009

Bergamaschi L et al. – Previous studies reported an association with multiple sclerosis (MS) of distinct HLA–class I markers, namely HLA–A*02, HLA–Cw*05 and MOG–142L. In the [more...]

Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
Arthritis & Rheumatism, 12/10/2009

Okada Y et al. – Heterogeneous risks of anti–CCP antibody positivity were confirmed among SE and non–SE alleles in the patient ... the HLA region that is independent of HLA–DRB1 was confirmed. [more...]

Human leukocyte antigen-G in ankylosing spondylitis and the response after tumour necrosis factor-&alpha blocker therapy
Rheumatology, 12/15/2009

poor spinal mobility. The expression of HLA-G on PMBCs is up-regulated in AS, correlates with acute phase reactants and decreases after TNF- blocker therapy, suggesting an index of disease activity. Methods Serum levels of soluble HLA-G (sHLA-G) measured in 80 AS patients and ... of HLA-G on peripheral blood mononuclear cell (PBMC) surface was investigated in same 80 AS patients and 40 healthy controls by flow cytometry Response of HLA-G after 3 months of TNF-&alpha blocker therapy (adalimumab) was evaluated in 14 AS patients We evaluated Bath Ankylosing ... to-floor distance and tragus-to-wall distance Expression of HLA-G on PBMCs significantly higher in 80 AS patients than 40 healthy controls , and correlated significantly with ESR and CRP Expression of HLA-G on PMBCs decreased significantly after 3 months of adalimumab therapy ... ul> [more...]

HLA-DR expression and differential trafficking of monocyte subsets following low to intermediate risk surgery
Anaesthesia, 12/07/2009

Handy JM et al. – The results suggest that surgery induces significant trafficking (i.e. mobilisation, margination and extravasation) of monocyte subsets, and that monocyte HLA&ndash ... DR depression is the result of a down–regulatory phenomenon (decreased protein expression on each cell) rather than the differential trafficking of monocyte subsets. [more...]

Diverging effects of HLA–DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles
Leukemia, 11/24/2009

Shaw BE et al. – The results suggest that in patients receiving an HLA–mismatched graft, the outcome is [more...]

HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell disease
Pediatric Blood & Cancer, 11/12/2009

McPherson ME et al. – This analysis is the first description of HLA alloimmunization in pediatric SCD patients who receive primarily leukoreduced RBC transfusions and demonstrates ... that HLA alloimmunization tendency is associated with antibodies to RBC antigens. [more...]