Top beta 2 Articles in Allergy/Immunology

Beta cell (dys)function in non-diabetic offspring of diabetic patients
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 10/12/2009

Stadler M et al. – The first–degree offspring of type 2 diabetic patients show insulin resistance and beta cell dysfunction in response to oral glucose challenge. Beta cell impairment exists in insulin&ndash ... sensitive offspring of patients with type 2 diabetes, suggesting beta cell dysfunction to be a major defect determining diabetes development in diabetic offspring. [more...]

The effects of glucagon-like peptide-1 on the beta cell
Diabetes, Obesity and Metabolism, 11/06/2009

Vilsboll T – Preclinical studies have shown that both liraglutide and exenatide treatment can increase beta–cell mass, stimulate beta–cell proliferation, increase beta–cell neogenesis and inhibit beta–cell apoptosis. Clinical ... these findings in humans. Replication of these data in humans could have important clinical implications for the treatment of type 2 diabetes. [more...]

Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
Acta Diabetologia, 10/29/2009

North KE et al. – One CHEK2 variant, rs4035540, was associated with an increased risk of type 2 diabetes in HyperGEN participants, two replication samples, and in the meta–analysis ... pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta–cell damage and apoptosis. [more...]

Estrone/17[beta]-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis
Arthritis & Rheumatism, 10/01/2009

Schmidt M et al. – Our findings indicate that precursor estrogens are converted to proinflammatory ... in RA synovial cells. RA synovial cells mainly produce the proproliferative 16OH-estrone, which, in addition to 16&alphaOH-17&beta-estradiol, is one of the only 2 estrogens studied that does not inhibit TNF secretion. A preponderance of 16&alpha-hydroxylated estrogens is an unfavorable sign in ... 17&beta-estradiol to various estrogen metabolites in RA and OA synovial cells Results Serum levels of estrone sulfate similar in healthy controls and RA Estrone sulfate transporters were present in synovial tissue. Interconversion of estrone and 17&beta-estradiol ... cytochrome P450 family were similar in RA and OA cells Using estrone and 17&beta-estradiol as substrates, RA and OA synovial cells produced 16&alphaOH -, 4-, and 2-hydroxylated estrogens and their 4- and 2-methylation products The levels of 16-hydroxylated estrone/17-estradiol (16OH [more...]

Polymorphism of the ADRB2 Gene and Response to Inhaled Beta- agonists in Children with Asthma: A Meta-analysis
Journal of Asthma, 11/10/2009

Finkelstein Y et al. – Failure of bronchodilator response to inhaled beta–agonists in asthmatic children is associated with the Gly allele (Arg/Gly and Gly/Gly genotypes) at position 16 of the beta–2&ndash ... receptor. Genetic typing for beta–2AR polymorphism may help identify children with drug–resistant asthma. [more...]

TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells
BMC: Journal of Biomedical Science, 10/26/2009

Tsai SH et al. – TGF–could prevent OA from progression with the anabolic ability to induce CTGF production to maintain extracellular matrix (ECM) integrity and to down ... PAR–2 expression, and the anti–catabolic ability to induce Tissue inhibitors of metalloproteinase–3 (TIMP–3) production to inhibit MMPs leading to avoid PAR–2 over–expression. Because IL–1–induced PAR–2 expressed in hPSCs might play a ... important role in early phase of OA, PAR–2 repression by exogenous TGF– or other agents might be an ideal therapeutic target to prevent OA from progression. [more...]

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function
Diabetes, 11/05/2009

Simonis–Bik AM et al. – Diabetes risk alleles in CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B are associated with various specific aspects of beta cell ... function. These findings point to a clear diversity in the impact that these different gene variants may have on (dys–)function of pancreatic beta cells. [more...]

Insulin Resistance, beta-Cell Dysfunction, and Conversion to Type 2 Diabetes in a Multiethnic Population: The Insulin Resistance Atherosclerosis Study (IRAS)
Diabetes Care, 10/14/2009

Lorenzo C et al. – Both insulin sensitivity and beta–cell function predict conversion to diabetes in different ethnic groups and ... glucose tolerance, family history of diabetes, and obesity. The prevention of type 2 diabetes should focus on interventions that improve both insulin resistance and insulin secretion. [more...]

Novel Genetic Environment of the Carbapenem-Hydrolyzing beta-Lactamase KPC-2 among Enterobacteriaceae in China
Antimicrobial Agents and Chemotherapy, 10/06/2009

Shen P et al. – The chimera of several transposon–associated elements indicated a novel genetic environment of the K. pneumoniae carbapenemase beta–lactamase gene in isolates from China. [more...]

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure
BMC Cardiovascular Disorders, 11/04/2009

Mansur AJ et al. – In this study sample, the authors were not able to demonstrate an overall influence of polymorphisms Gln27Glu and Arg16Gly of beta–2 receptor gene on prognosis [more...]