Anaphylaxis and angioedema
Dermatology in Practice, 10/09/2009
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Anaphylaxis represents the most severe form of immediate allergic reaction and is due to the presence of immunoglobulin E (IgE) antibodies (type I hypersensitivity). Angioedema refers to localised deep tissue swelling and can occur as part of an anaphylactic reaction ... immunology,dermatopathology,dermatology
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Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency
Journal of Allergy and Clinical Immunology, 10/07/2009
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Bossi F et al. – The data suggest that both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma.
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Human C1-Esterase Inhibitor Concentrate (Berinert(R))
BioDrugs, 11/10/2009
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is derived from human plasma and is indicated for the treatment of acute episodes of hereditary angioedema. Intravenous C1–INH concentrate was well tolerated in patients with hereditary angioedema, with no confirmed cases of viral transmission.
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Pathogenesis and laboratory diagnosis of hereditary angioedema
Allergy and Asthma Proceedings, 10/09/2009
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Zuraw BL et al. – The knowledge gained concerning the underlying mechanisms of the different types of HAE allow the clinician to approach the laboratory diagnosis with confidence and provides opportunities for novel therapeutic ... immunology,dermatology,diagnostics/radiology,radiology/diagnostics
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Supraglottic swelling may not correlate with tongue swelling in angiotensin converting enzyme inhibitor-induced angioedema
The Laryngoscope, 11/06/2009
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Saxena S et al. – The authors present a representative case. This observation suggests that all patients with ACEI–induced angioedema should undergo laryngeal fiberoptic examination and appropriate airway
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Frequency, timing, and type of prodromal symptoms associated with hereditary angioedema attacks
Allergy and Asthma Proceedings, 10/14/2009
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Prematta MJ et al. – Prodromes occur frequently before HAE attacks. This high frequency suggests that prodromal symptoms could be a reliable indication to begin treatment to prevent an acute HAE ... derm allergy/immunology
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Update on therapeutic developments for hereditary angioedema
Allergy and Asthma Proceedings, 10/12/2009
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Christiansen SC et al. – Potential options for the acute treatment of HAE will be discussed including purified C1INH, recombinant C1INH, an inhibitor of plasma kallikrein, and a B2–receptor antagonist. The arrival of these ... management of HAE.
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Variability of prodromal signs and symptoms associated with hereditary angioedema attacks: A literature review
Allergy and Asthma Proceedings, 10/12/2009
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Kemp JG et al. – The review indicates that there is significant variability in the expression, manifestation, prevalence, timing, and predictive reliability of the prodromes that ... manifestations that may occur before or during HAE attacks. The authors have not found any evidence that their sensitivity and specificity for accurately predicting such attacks has been studied.
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Pharmacokinetic analysis of human plasma–derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: a prospective study
Transfusion, 10/01/2009
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Martinez–Saguer I et al. – pC1–INH concentrate has a long median terminal elimination half–life and rapidly reaches ... anaphylaxis,transfusion medicine
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Inherent inaccuracies and potential utility of race/ethnicity labeling in the treatment of hypertension
Journal of the American Society of Hypertension, 10/15/2009
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of sodium and lower levels of potassium may respond better to diuretics and calcium antagonists. Other populations may be more susceptible to angioedema or cough related to the use of angiotensin–converting enzyme inhibitors. Such information may be useful for the selection or avoidance of
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