Calderwood AH et al. – Previous findings on renal pelvis/ureteral cancer and a follow up of the history of colorectal cancer (CRC) supports a possible common pathogenetic mechanism between CRC and urologic cancers and may have implications for screening guidelines. Methods
Study to quantify the risk for CRC after urologic cancer and the risk for urologic cancer after CRC in pts w/o known genetic syndromes
A retrospective cohort analysis of the Surveillance, Epidemiology, and End Results from program database from 1973 to 2000 was performed
Standard incidence ratios (SIRs) of observed to expected cases of invasive CRC were calculated for each urologic cancer site based on age, sex, ethnicity, and calendar year of diagnosis
Similar analysis was performed to determine the SIRs of urologic cancers in pts with previous CRC
Results
Overall, the risk for CRC was increased among pts with previous ureteral cancer and renal pelvis cancer
This risk was greatest among pts who received the diagnosis of renal pelvis or ureteral cancer before the age of 60 yrs
There was a minimal increased risk for subsequent CRC in pts with bladder or renal parenchymal cancer
Overall, the risk for urologic cancer was increased after a diagnosis of CRC
Highest risk for subsequent renal pelvis and ureteral cancers was observed in pts with a CRC diagnosis before the ages of 50-60 yrs or multiple primary CRCs
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