Top valsartan Articles in Urology

FDA gives nod to new combination therapy for hypertension
Internet Source, 09/23/2009

300 mg doses of aliskiren and 160 mg and 320 mg doses of valsartan alone and in combination. The doses were increased to 300 mg of aliskiren and 320 mg of valsartan at four weeks. They reported that the combination aliskiren and valsartan reduced BP to a greater extent than the monotherapies alone ... diastolic BP from baseline were 17.2/12.2 mm Hg for the combination of aliskiren 300 mg and valsartan 320 mg, compared with 12.8/9.7 mm Hg for valsartan 320 mg alone, 13.0/9.0 mm Hg for aliskiren 300 mg alone and 4.6/4.1 mm Hg for placebo. [more...]

Exforge (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact
Core Evidence, 08/14/2009

Krzesinski J–M et al. – The amlodipine/valsartan combination is an association of two well–known antihypertensive products with specific targets in cardiovascular protection, namely ... amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage. [more...]

Valsartan ingestions among adults reported to Texas poison control centers, 2000 to 2005
Journal of Medical Toxicology, 11/10/2009

Forrester MB et al. – The severity of the medical outcome associated with adult valsartan ingestions depended on the dose and the circumstances of the ingestion. Such information is useful for creating ... triage guidelines for the management of adult valsartan ingestions. [more...]

Randomized study to compare valsartan ± HCTZ versus amlodipine ± HCTZ strategies to maximize blood pressure control
Vascular Health and Risk Management, 10/23/2009

Zappe D et al. – At study end, 78.8% of patients on valsartan ± HCTZ were controlled (BP < 140/90 mmHg) and still on study medication versus 67.8% on amlodipine ± HCTZ ... had a higher incidence of peripheral edema (22.4% vs 2.2%) and associated discontinuations (7.3% vs <1%). Initiating therapy earlier with valsartan/HCTZ, rather than titrating monotherapy to its maximum dose before adding a second agent, was superior to amlodipine monotherapy or amlodipine ± HCTZ [more...]

A randomized, double-blind, placebo-controlled study to determine the effects of valsartan on exercise time in patients with symptomatic heart failure with preserved ejection fraction
European Journal of Heart Failure, 10/06/2009

Parthasarathy1 HK et al. – In this population, which predominantly included patients with well–controlled hypertension and symptomatic HFPEF, addition of valsartan did not increase ... exercise time within 14 weeks. However, valsartan 320 mg reduced blood pressure and improved symptoms of perceived exertion (Borg score) during exercise and was generally well–tolerated. [more...]

Renal protective effect of RAAS blockade across the renal continuum, with a review of the efficacy and safety of valsartan
Current Medical Research and Opinion, 10/22/2009

Locatelli F et al. – Valsartan has been studied extensively and is widely used for the management of hypertension. Data from clinical studies involving valsartan and other ARBs and ACE inhibitors provide evidence of an ... apparently arises from hemodynamic, endothelial, and anti–inflammatory actions. [more...]

Effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high cardiovascular risks: KYOTO HEART Study
European Heart Journal, 09/03/2009

Sawada T et al. – Valsartan add–on treatment to improve blood pressure control prevented more cardiovascular events than conventional non–ARB ... high–risk hypertensive patients in Japan. These benefits cannot be entirely explained by a difference in blood pressure control. [more...]

The Role of Baseline Blood Pressure in Guiding Treatment Choice: A Secondary Analysis of the Use of Valsartan/Hydrochlorothiazide as Initial Therapy in Hypertensive Adults in a Randomized, Double-Blind, Placebo-Controlled Trial
Clinical Drug Investigation, 11/12/2009

Pool JL et al. – The secondary analyses suggest that ... hypertensive population. Initial therapy with the combination of valsartan/HCTZ is more effective than monotherapy in lowering BP at all baseline BP levels, is consistent in this respect among all subgroups, and is well tolerated. [more...]

Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy
Current Medical Research and Opinion, 09/15/2009

Schunkert H – The combination of amlodipine/valsartan in this 8–week double–blind study provided additional BP control and was well [more...]

Amlodipine/Valsartan Single-Pill Combination: A Review of its Use in the Management of Hypertension
American Journal of Cardiovascular Drugs, 10/08/2009

Frampton JE et al. – Amlodipine/valsartan offers a rational and convenient treatment option for the management of patients with hypertension, the majority of whom will require at least two [more...]