Hepatocyte Growth Factor (HGF) Modulates Leydig Cells Extracellular Matrix Components
Journal of Andrology, 10/26/2009
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Catizone A et al. – The presented data demonstrate that HGF modulates several functional activity of Leydig cells, further supporting the hypothesis that this factor exerts a relevant role in the regulation ... science/genetics,infertility,urology
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Peripheral insulin-like factor 3 (INSL3) concentrations are reduced in men with type 2 diabetes mellitus: effect of glycemic control and visceral adiposity on Leydig cell function
European Journal of Endocrinology, 09/22/2009
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Ermetici F et al. – Hypogonadism frequently occurs in men with type 2 diabetes mellitus (T2DM), while the role of glycemic control and visceral obesity is still unclear. This study aimed to assess the Leydig cell function, including the new ... in T2DM patients without overt hypogonadism and the influence of either glycemic control or visceral adiposity. An early impairment of the overall Leydig cell function is present in men with T2DM, mainly related to visceral adiposity rather than to glycemic control.
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Ovarian Hyperthecosis and Stromal Leydig Cell Tumor in a Postmenopausal Woman With Virilization
The Endocrinologist, 11/18/2009
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Vijaykumar S et al. – The authors report a rare case of bilateral ovarian hyperthecosis concealing a stromal Leydig cell tumor in a postmenopausal woman with virilization. Stromal Leydig cell tumor is exceedingly rare
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Insulin-like factor 3 as a marker of testicular function in obese men
Clinical Endocrinology, 10/16/2009
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showed for the first time that INSL3 levels decrease with obesity, probably as a result of a primary dysfunction of the Leydig cells. INSL3 is a reliable marker of Leydig cell general impairment, whereas T mainly reflects the steroidogenic activity of these cells.
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Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism
International Braz J Urol, 11/04/2009
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Tasian GE et al. – Testes that remain undescended are associated with progressive loss of germ and Leydig cells, and nonpalpable testes predict severe germ cell
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Testicular tumours of adrenogenital syndrome
Diagnostic Histopathology, 08/06/2009
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as bilateral testicular masses in patients with congenital adrenal hyperplasia. Attempt at differentiation from the morphologically similar Leydig cell tumour on biopsy tissue has potential for misdiagnosis; however, this distinction is crucial due to significantly different clinical interventions
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Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis
Journal of Clinical Endocrinology and Metabolism, 10/21/2009
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Fowler PA et al. – Falling second–trimester fetal testosterone is probably due to declining maternal hCG because Leydig cell LH/hCG responsiveness remains constant. Although maternal cigarette smoking reduces fetal hCG, the ratio of inactive LHCGR isoforms is
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P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure
International Journal of Andrology, 11/13/2009
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subjects with impaired spermatogenesis. However, an altered intratesticular oestradiol/testosterone ratio in some patients with complete SCOS suggests that aromatase is increased, which might contribute to Leydig cell dysfunction.
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Normal Spermatogenesis in a Man with Mutant Luteinizing Hormone
New England Journal of Medicine, 11/05/2009
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Achard C et al. – The residual luteinizing hormone activity, resulting in the expression of steroidogenic enzymes in few mature Leydig cells producing small amounts of intratesticular testosterone (20.2 ng per gram), was sufficient for complete and quantitatively normal
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Late diagnosis of cryptorchidism
Der Urologe, 08/25/2009
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ndash; Sonographically, no parenchymal echotexture abnormalities were found. A–dark spermatogonia could be detected in nine biopsies. The Leydig cell score was reduced in 11 boys. No carcinoma in situ cells were detected. Late diagnosis of undescended testis will have a poor prognosis for
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