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The role of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as a prognostic marker in older people: the impact of reduced renal function
Reviews in Clinical Gerontology, 11/10/2009
Axelsson TG et al. – The N–terminal pro–brain natriuretic peptide (NT–pro–BNP) is released in response to volume expansion ... on left ventricular myocytes. NT–pro–BNP is a useful diagnostic and prognostic biomarker both in patients with dyspnoea of unknown aetiology, and for risk assessment of patients with established heart failure. However, impaired kidney function – a common condition in older people as well ... cardiovascular disease is associated with elevated circulating levels of NT–pro–BNP. Therefore, it is important to know the kidney function when interpreting an elevated NT–pro–BNP measurement obtained in older people in order to diagnose or stage congestive heart failure ... nephrology [more...]

Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis
International Immunology, 10/14/2009
Hong J et al. – MBP–specific autoreactive T cells are considered pro–inflammatory T cells and thought to play an important role in the pathogenesis of multiple sclerosis ... provides new evidence that MBP–specific T cells are susceptible to pro–inflammatory cytokine milieu and act as either pro–inflammatory or regulatory T cells. [more...]

Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth
European Journal of Obstetrics & Gynecology and Reproductive Biology, 11/20/2009
Ervasti M et al. – The present results suggest that pro–hepcidin is not associated with maternal or newborn iron homeostasis at term and birth, but may act in concert with the placenta, as evidenced by the ... correlation between maternal and fetal pro–hepcidin levels and their slight correlation with placental weight. [more...]

Beneficial Potential of Casein Hydrolysate Containing Val-Pro-Pro and Ile-Pro-Pro on Central Blood Pressure and Hemodynamic Index: A Preliminary Study
Journal of Medicinal Food, 11/05/2009
Nakamura T et al. – This study suggests that continuous intake of VPP and IPP might have the potential to improve arterial stiffness as well [more...]

Once-Weekly Administration of Etanercept 50 mg Improves Patient-Reported Outcomes in Patients with Moderate-to-Severe Plaque Psoriasis
Dermatology, 10/23/2009
ndash;to–severe psoriasis entered this trial with serious PRO impairment. At week 12, etanercept 50 mg QW provided significant QoL improvements compared with placebo. After 24 weeks of etanercept, the patients' serious PRO impairment had largely abated. [more...]

Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetes
Diabetes Care, 10/28/2009
Liu L et al. – The results indicated that the Pro/Pro genotype and smoking were significant independent risk factors for diabetic nephropathy. The possible synergistic effects of genotype and smoking may [more...]

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes
Osteoarthritis and Cartilage, 10/23/2009
Kim J et al. – Mitochondrion is an important target in pro–inflammatory cytokine toxicity, maintaining of mitochondrial DNA integrity is necessary to prevent chondrocytes [more...]

Antioxidants in the prevention of atherosclerosis: The importance of proper patient selection
Clinical Nutrition, 10/15/2009
Levy Y et al. – The authors believe that groups with evidence of a significant pro–oxidative and pro–inflammatory milieu such as the diabetic patients with the Hp 2–2 genotype, may benefit from antioxidants. Thus, better [more...]

Impact of CPAP treatment on cardiac biomarkers and pro-BNP in obstructive sleep apnea syndrome
Sleep and Breathing, 10/21/2009
Cifci N et al. – Obstructive sleep apnea syndrome does not induce myocardial damage enough to increase serum pro–BNP, CK, CK–MB, troponin I, and AST levels. Markers sensitive to [more...]

Update and commentary on the pro-drug bimatoprost and a putative prostamide receptor
Expert Review of Ophthalmology, 10/21/2009
Sharif NA et al. – While it is generally believed that bimatoprost is a pro–drug and that bimatoprost free acid is the active moiety involved in lowering IOP, some have proposed that bimatoprost exerts [more...]

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