Fungal Leukocytoclastic Vasculitis as a Presentation of Systemic Vasculitis in a Patient With Systemic Lupus Erythematosus
Journal of Clinical Rheumatology (JCR), 12/11/2009
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Wasserman AM et al. – Patients with systemic lupus erythematosus (SLE) commonly have vasculitis with cutaneous involvement. The authors describe a young woman with SLE ... leukocytoclastic vasculitis due to Candida albicans.
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Rituximab may form a complex with iGm[kappa] mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virus-induced vasculitis
Arthritis & Rheumatism, 12/03/2009
Sène D et al. – In HCV-associated MC vasculitis, rituximab may form a complex with RF-positive IgM, leading to accelerated cryoprecipitation and to severe systemic reactions. Rituximab should be administered with caution in MC vasculitis, with use of the 375 mg protocol ... rituximab infusion in patients with high baseline levels of mixed cryoglobulin. Methods- 22 HCV-infected patients with MC vasculitis received rituximab infusions (a low-dose protocol cycle with 375 mg/m2/week for 4 consecutive weeks in 18 patients and a high-dose protocol cycle ... ul>
- 6 of 22 patients (27.3%) experienced systemic drug reactions after rituximab infusion
- 4 patients developed severe flare of MC vasculitis 1 or 2 days after rituximab infusion
- 2 patients developed serum sickness syndrome 7 and 9 days after first 1,000 mg rituximab infusion
- In vitro addition of rituximab to serum containing an RF-positive IgM type II mixed cryoglobulin associated with visibly accelerated cryoprecipitation
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Vasculitis-like syndromes
Current Rheumatology Reports, 12/09/2009
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Bateman H et al. – Vasculitis often presents a diagnostic challenge as the disease processes may have varied presentations. This article reviews some vasculitis–like "mimics," particularly emphasizing viral and bacterial infections, drug–related ... disorders, various malignancies, and other autoimmune disorders, all of which may have a similar clinical presentation.
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Small vessel vasculitis
Pediatric Nephrology, 11/11/2009
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Brogan P et al. – Significant challenges remain in the field of pediatric small vessel vasculitis, including the development of validated disease outcome measures and biomarkers to be used in clinical trials. Lastly, long–term outcome data are lacking in ... pediatric small vessel vasculitis.
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Systemic vasculitis in childhood
Current Rheumatology Reports, 12/03/2009
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Gedalia A et al. – Systemic vasculitis is a group of disorders with multiorgan involvement. These disorders have diverse clinical manifestations associated with significant morbidity and mortality. This article offers an overview of the epidemiologic ... pathophysiologic, and clinical features of vasculitis in children, with emphasis on common conditions.
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Ciprofloxacin-Induced Hemorrhagic Vasculitis
Annals of Vascular Surgery, 11/09/2009
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Berg FPVD et al. – Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin–induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication ... faulty diagnosis and treatment. The intention of this case report is to raise awareness for anyone prescribing ciprofloxacin as treatment for infected diabetic and ischemic ulcers.
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Serum concentrations of interleukin 1î², cxcl10, and interferon-î³ in mixed cryoglobulinemia associated with hepatitis c infection
Journal of Rheumatology, 11/20/2009
levels of IL-1ß and CXCL10 were high in patients with MC+HCV. Increased CXCL10 and IL-1ß levels were associated with the presence of active vasculitis in MC+HCV patients. Methods- Serum IL-1ß, IFN-?, and CXCL10 were assayed in 54 patients with MC+HCV, in 54 sex- and age-matched ... increased in 14 cryoglobulinemic patients with active vasculitis (necrotizing vasculitis or vasculitic skin ulcers) compared to those without (p < 0.001); IL-1ß was increased in cryoglobulinemic patients with active vasculitis (p = 0.06).
- No differences were observed for serum IFN-? levels
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The other vasculitis syndromes and kidney involvement
Pediatric Nephrology, 11/11/2009
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Ozen S – Studies carried out during the past decade have provided valuable information on the mechanism of inflammation and innate immunity in general. This group of vasculitides is associated with secondary amyloidosis of the kidney if ... Hypocomplementemic urticarial vasculitis is an interesting vasculitic disease with frequent kidney involvement.
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Isolated CNS vasculitis: Unusual presentation of relapsed Ewing sarcoma
Pediatric Blood & Cancer, 11/12/2009
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Stepensky P et al. – Complete neurologic recovery was achieved on prednisone. Four months later the patient developed overt, extensive metastases, confirmed by biopsy to represent recurrent Ewing sarcoma. Despite ... the patient succumbed 6 months later. This case demonstrates the unique finding of isolated CNS vasculitis as a presenting sign of Ewing sarcoma.
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Medium-size-vessel vasculitis
Pediatric Nephrology, 12/04/2009
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Dillon MJ et al. – An infectious trigger and a genetic predisposition seem likely. Intravenous immunoglobulin (IV–Ig) and aspirin are effective therapeutically, but in resistant cases, either steroid or infliximab have a role. Greater understanding of the ... mechanisms involved in these three types of vasculitis and better long–term follow–up data will lead to improved therapy and prediction of prognosis.
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