Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease
Archives of Neurology, 10/14/2009
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Ascherio A et al. – Higher serum and cerebrospinal fluid urate concentrations at baseline were associated with slower rates of clinical decline. The findings strengthen the link between urate concentration and PD and ... the rationale for considering central nervous system urate concentration elevation as a potential strategy to slow PD progression.
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Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease
Archives of Neurology, 12/16/2009
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Ascherio A et al. – Higher serum and cerebrospinal fluid urate concentrations at baseline were associated with slower rates of clinical decline. The findings strengthen the link between urate concentration and PD and ... the rationale for considering central nervous system urate concentration elevation as a potential strategy to slow PD progression.
[more...]
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Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia
Cancer, 10/26/2009
Crews KR et al. – The lower rate of methotrexate clearance in patients who received allopurinol likely reflected a less potent hypouricemic effect of ... nonrecombinant or recombinant urate oxidase (n = 96) during high-dose methotrexate administration before conventional remission induction therapy comparedResults- Minimum plasma concentration of uric acid significantly lower after urate oxidase treatment than concentration ... significantly higher in patients who received urate oxidase
- Higher proportion of patients in allopurinol group had elevated methotrexate plasma concentrations and experienced mucositis after methotrexate treatment compared with urate oxidase group
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Investment in Parkinsons Disease Data Bank Yields Potential Therapy
NIH, 10/14/2009
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of a metabolite called urate in their blood and in cerebrospinal fluid have a slower rate of disease progression, according to a study funded by the National Institutes of Health. A clinical trial is under way to examine the safety and potential benefits of supplemental urate elevation for recently ... patients who have low urate levels.
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Investment in Parkinsons disease data bank yields potential therapy
EurekAlert, 10/13/2009
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of a metabolite called urate in their blood and in cerebrospinal fluid have a slower rate of disease progression, according to a study funded by the National Institutes of Health. A clinical trial is under way to examine the safety and potential benefits of supplemental urate elevation for recently ... patients who have low urate levels.
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SLC22A12 Gene is Associated with Gout in Han Chinese and Solomon Islanders
Annals of Rheumatic Diseases, 09/30/2009
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ndash; Gout is characterised by monosodium urate crystals in hyperuricemic individuals. Impaired excretion of urate exacerbates this condition. The authors studied four SLC22A12 single–nucleotide polymorphisms' (SNPs) associations with gout and urate levels in male Han Chinese of Taiwan and
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The role of urate and xanthine oxidase in vascular oxidative stress: future directions
Therapeutics and Clinical Risk Management, 10/07/2009
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George J et al. – This article highlights the potential avenues of further research such as dose–response, and the potential for these agents to regress left ventricular hypertrophy. The role of ... the current newer agents have failed to live up to the promising early–phase data. It is crucial that these remaining questions surrounding urate, xanthine oxidase and the role of various agents that affect this important oxidative stress–generating system are answered, and therefore ... medicine,clinical pharmacology,prevention
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Gout
The Clinical Advisor, 09/21/2009
Brier M – Disorder with a heterogeneous group of clinical presentations resulting from tissue deposition of monosodium urate crystals.
Testing: - Synovial fluid analysis/culture needed to exclude septic arthritis if patient is febrile and has leukocytosis
- Serum ... ndash;ray may help confirm.
- 24–hour urine uric acid level as adjunctive test for 1) Identifying/excluding overproducers of urate 2) Patients being considered for uricosuric therapy
- Blood culture to rule out infection
Treatment of acute attack: - Oral ... fluid intake (>2 L water daily).
- Allopurinol should not be started or discontinued during acute attack (avoid sudden changes in serum urate levels).
- Consider discontinuation of diuretics.
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Study supports possible role of urate in slowing Parkinsons disease progression
EurekAlert, 10/13/2009
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By examining data from a 20–year–old clinical trial has found evidence supporting the findings of their 2008 study that elevated levels of the antioxidant urate may slow the progression of Parkinson's
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Urate in blood and spinal fluid may predict slower decline in patients with Parkinsons disease
EurekAlert, 10/13/2009
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Higher concentration of urate in the blood and spinal fluid of patients with early Parkinson's disease is associated with slower rates of clinical decline, according to a report.
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