Top urate Articles in Rheumatology

Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease
Archives of Neurology, 10/14/2009

Ascherio A et al. – Higher serum and cerebrospinal fluid urate concentrations at baseline were associated with slower rates of clinical decline. The findings strengthen the link between urate concentration and PD and ... the rationale for considering central nervous system urate concentration elevation as a potential strategy to slow PD progression. [more...]

Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia
Cancer, 10/26/2009

Crews KR et al. – The lower rate of methotrexate clearance in patients who received allopurinol likely reflected a less potent hypouricemic effect of ... nonrecombinant or recombinant urate oxidase (n = 96) during high-dose methotrexate administration before conventional remission induction therapy compared Results Minimum plasma concentration of uric acid significantly lower after urate oxidase treatment than concentration ... significantly higher in patients who received urate oxidase Higher proportion of patients in allopurinol group had elevated methotrexate plasma concentrations and experienced mucositis after methotrexate treatment compared with urate oxidase group [more...]

Investment in Parkinsons Disease Data Bank Yields Potential Therapy
NIH, 10/14/2009

of a metabolite called urate in their blood and in cerebrospinal fluid have a slower rate of disease progression, according to a study funded by the National Institutes of Health. A clinical trial is under way to examine the safety and potential benefits of supplemental urate elevation for recently ... patients who have low urate levels. [more...]

Investment in Parkinsons disease data bank yields potential therapy
EurekAlert, 10/13/2009

of a metabolite called urate in their blood and in cerebrospinal fluid have a slower rate of disease progression, according to a study funded by the National Institutes of Health. A clinical trial is under way to examine the safety and potential benefits of supplemental urate elevation for recently ... patients who have low urate levels. [more...]

The role of urate and xanthine oxidase in vascular oxidative stress: future directions
Therapeutics and Clinical Risk Management, 10/07/2009

George J et al. – This article highlights the potential avenues of further research such as dose–response, and the potential for these agents to regress left ventricular hypertrophy. The role of ... the current newer agents have failed to live up to the promising early–phase data. It is crucial that these remaining questions surrounding urate, xanthine oxidase and the role of various agents that affect this important oxidative stress–generating system are answered, and therefore ... medicine,clinical pharmacology,prevention [more...]

Study supports possible role of urate in slowing Parkinsons disease progression
EurekAlert, 10/13/2009

By examining data from a 20–year–old clinical trial has found evidence supporting the findings of their 2008 study that elevated levels of the antioxidant urate may slow the progression of Parkinson's [more...]

Urate in blood and spinal fluid may predict slower decline in patients with Parkinsons disease
EurekAlert, 10/13/2009

Higher concentration of urate in the blood and spinal fluid of patients with early Parkinson's disease is associated with slower rates of clinical decline, according to a report. [more...]

Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells
Arthritis Research & Therapy, 10/12/2009

Capsoni F et al. – alpha-MSH and (CKPV)2 have a dual effect on MSU crystal-induced inflammation, inhibiting the Mo's ability to produce neutrophil chemoattractants and activating compounds and preventing the ... as a new class of drugs for treatment of inflammatory arthritis. Methods Purified monocytes (Mo) stimulated with monosodium urate (MSU) crystals in presence or absence of melanocortin peptides The supernatants were tested for ability to induce neutrophil activation in [more...]

Reference Values for 27 Clinical Chemistry Tests in 70-Year-Old Males and Females
Gerontology, 10/21/2009

HDL–cholesterol, iron, lactate dehydrogenase, LDL–cholesterol, magnesium, phosphate, potassium, sodium, transferrin, triglycerides, urate and urea. Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance. Several [more...]

Tophaceous gout: an unusual cause of multiple fractures
Scandinavian Journal of Rheumatology, 10/20/2009

Nguyen C et al. – Monosodium urate (MSU) crystals can contribute to bone lesions by reducing osteoblastic activity and are associated with enhanced osteoclast activity in the vicinity of tophi. Mild trauma triggers MSU crystal release from [more...]