Top sjogrens Articles in Rheumatology

Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogrens syndrome
Current Opinion in Rheumatology, 08/18/2009

Perl A - Review concludes that discovery of novel genes and signaling pathways in lupus pathogenesis offers novel biomarker-targeted approaches for treatment of systemic lupus erythematosus (SLE) and Sjogren's syndrome. Methods Sjogren's syndrome Results Mammalian target of rapamycin (mTOR) in T and B cells has been successfully targeted for treatment of SLE with rapamycin or sirolimus Inhibition of below listed pathways ... cell depletion and blockade of anti-DNA Abs and T-B cell interaction have shown success in animal models as well However, human studies have so far failed to accomplish clinical endpoints, possibly due to inadequacies in study design [more...]

Systemic light chain amyloidosis and Sjogren syndrome: an uncommon association
Amyloid The Journal of Protein Folding Disorders, 09/02/2009

Perlat A et al. – The authors present a patient who presented simultaneously with Sjogren syndrome (supported by dry mouth, positive Schirmer's test, anti–Ro/SSA antibodies, and a lower lip salivary gland [more...]

Implications of immunomodulatory interleukins for the hyperimmunoglobulinemia of Sjogren’s syndrome
Cellular Immunology, 09/03/2009

Giron–Gonzalez JA et al. – Patients with pSS show a state of macrophage and T–lymphocyte activation with increased concentrations of cytokines implicated in the differentiation of ... rheumatic/autoimmune [more...]

B cell depletion in lupus and Sjogrens syndrome: An update
Current Opinion in Rheumatology, 08/18/2009

Coca A et al. – Study reports that despite the disappointing results of 2 phase III trials, other evidence continues to be published in support of the notion that B cell depletion could be useful for patients with refractory disease ... levels B cell depletion seemed quite efficacious also in pediatric SLESjogren's syndrome; incidental reports on efficacy have been recently published [more...]

Pathogenesis of Sjogren's syndrome
Current Opinion in Rheumatology, 08/14/2009

Nikolov NP et al. – Recent discoveries from studies in patients with Sjögren's syndrome suggest a complex interplay between genetic factors, environmental and stochastic events that involve innate and adaptive immunity, hormonal mechanisms and the autonomic ... Some of these findings suggest that exocrine gland dysfunction may precede autoimmunity or represent a process independent from inflammation in the pathogenesis of Sjögren's syndrome. [more...]

Cells with regulatory function of the innate and adaptive immune system in primary Sjogren's syndrome
Clinical and Experimental Immunology, 08/13/2009

Szodoray P et al. – Serum IL–6 and TNF–alpha levels were elevated, while IL–10 was decreased in patients compared to controls. Negative correlation was found between IL ... of regulatory cells in pSS may contribute to the development and progression of the disease. [more...]

Hematologic manifestations and predictors of lymphoma development in primary Sjogren syndrome: clinical and pathophysiologic aspects
Medicine, 09/15/2009

Baimpa E et al. – Anemia of chronic disease and hypergammaglobulinemia are common hematologic manifestations at diagnosis and during the course of pSS. Neutropenia ... factors Disease characteristics could predict subsequent development of MZBCL Presence of lymphocytopenia at diagnosis served as risk factor for the development of a non-MZBCL [more...]

Genetics of systemic lupus erythematosus and Sjogrens syndrome
Current Opinion in Rheumatology, 08/17/2009

Scofield RH - Review attempts to highlight the fact that knowledge of genetics of systemic lupus erythematosus (SLE) is advancing rapidly, whereas that of Sjögren's syndrome lags behind considerably. Methods Aim was [more...]

Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome
Autoimmunity, 08/10/2009

Burbelo PD et al. – These heterogeneous autoantibody responses detected by LIPS in SjS will likely be useful for diagnosis and for evaluating extraglandular manifestations. [more...]

The minor salivary gland biopsy as a diagnostic tool for Sjogren syndrome
The Laryngoscope, 08/05/2009

Bamba R et al. – The results of this study suggest that patients with clear criterion for SS may not require a lip biopsy, especially those patients on immunosuppression. When physicians suspect SS, a thorough clinical [more...]